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pentobarbital decreases amounts of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can reduce panobinostat amounts by ~70% and bring about therapy failure.pentobarbital will minimize the level or effect of celecoxib by influencing hepatic enzyme CYP2C9/10 metabolism. Small/Significance